Endocrine Abstracts

Low plasma SHBG levels in overweight individuals are a biomarker for the metabolic syndrome and are predictive of type 2 diabetes and risk of cardiovascular disease. There are no in vivo models to study SHBG expression and regulation during obesity development. The main reason for this is that the obesity-prone rodent models cannot be used to study this issue since rodents unlike humans do not express the SHBG gene in their livers. We have developed by crossi...

Low circulating sex hormone-binding globulin (SHBG) is an independent risk factor for cardiovascular disease. Mediterranean diet has been associated with a decreased risk of cardiovascular disease. We have recently shown that olive oil consumption is associated with elevated SHBG serum levels and that PPARγ downregulation induced by oleoyl-CoA is an important underlying mechanism of such regulation. Red wine is also an important component of the Mediterranean diet and its...